The Making of a Disease
By: Jackie Clark
While it has long been known that exposure to asbestos has been found to be a causative factor in mesothelioma (http://www.mesothelioma.com/), it is less understood exactly how the exposure will later morph into the disease itself. Recently, there has been much study into the effects of asbestos on the genetic makeup of the tissues it affects in the hopes that identifying these changes can assist in early diagnosis and a better life expectancy in association with mesothelioma.
Wikileaks and released reports are best examples of thermodynamic laws stating that everything in the universe has a tendency towards disorder. Examples are various. When a water pipe breaks, water leaks. When glass is broken glass pieces are dispersed. When you do not clean your appartment the pleace will be a mess. Secret reports have a tendency to disseminate too.
Only, DNA gets against this rule. DNA creats itself from scratch and then organizes an individual. The individuls organize a living ecosystem etc, etc..
Tumor suppressor genes by definition are genes that are coding for proteins acting as a break on cancer. This group of genes function as a break mechanism when cells accelerate towards cancer. In basic terminology, the role of tumor suppressors is to stop cancer cells. P53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus directly functions as a tumor suppressor by stopping cell cycle or by killing the cancer cells by apotheosis.
Functional SNP assessment.
Although the relationship between risk allele and causation is still in its infancy23, some phenotypic traits can possibly be inferred from the genome data (all functional SNPs discussed below are listed in Supplementary Table 14). We only included genotypes with a posterior probability above 99%.
Pharma, biotech and agriculture markets as well as academic institutions are craving for DNA sequence information as their future is depending on genome data in silico. Scientists understand the business side of the sector, and realize that outsourcing can be a pretty cost efficient way to get the data they need, rather than investing in the resources to perform the sequencing in their labs. In addition, outsourcing gives these institutions the ability to focus their efforts on their core competencies, usually drug discovery and development, instead of acquiring the tools for sequencing.
The Genome Reviews database provides an up-to-date, standardized and comprehensively annotated view of the genomic sequence of organisms with completely deciphered genomes. Currently, Genome Reviews contains the genomes of archaea, bacteria, bacteriophages and selected eukaryota. Genome Reviews is available as a MySQL relational database, or a flat file format derived from that in the EMBL Nucleotide Sequence Database.
MySQL is a convenient platform for open source data transactions. That means genetic data of nearly all available species can be uploaded and retrieved.
Jan. 21, 2010: Toyota recalls 2.3 million Toyota vehicles in a U.S. since a accelerator pedal can stick, causing unintended acceleration. It is not associated to a building pad recall, nonetheless about 1.7 million of a vehicles have been additionally concerned in both recalls. Models concerned have been a 2009-2010 RAV4, 2009-2010 Corolla, 2009-2010 Matrix, 2005-2010 Avalon, sure 2007-2010 Camrys, 2010 Highlander, 2007-2010 Tundra, 2008-2010 Sequoia.
Jan. 26: Toyota at a moment suspends U.S. sales of a 8 models whose accelerator pedals can stick.
It is not as complicated as you think as long as you stick on the recipe.
1. Apply POI (Perturbation Of Interest) to your cells.
This could be a drug treatment, hyper- or hypo- oxia treatment or simply disease cells.
2. Get your normal control, untreated cells ready.
Now we are going to take molecular genetics pictures of your cells.
3. Spin down your cells.
4. Isolate RNA.
5. Get the cDNA copy of the RNA.
The cDNA copy of your cells represents the most recent status of cells of interest. Ready to take the picture.