Bioinformatics and AVATAR
DNA is the blue print of the genetic information. Imagine, your genes are special text recipes for proteins. The taste of a dish is based on content of a recipe. Experienced gourmets can even judge a dish based on the recipe alone. As an analogy, it can be determined whether a protein is cancerous or not just based on the genetic blue print information on your DNA alone. DNA based diagnostics is much more reliable than the protein based diagnostics.
Avandia is an oral medication used to treat Type II diabetes. It is manufactured by GlaxoSmithKline and was approved by the FDA. So far the diabetes drug has been used by over 6 million people worldwide, and could be responsible for thousands of heart attacks and deaths every year.
Functional SNP assessment.
Although the relationship between risk allele and causation is still in its infancy23, some phenotypic traits can possibly be inferred from the genome data (all functional SNPs discussed below are listed in Supplementary Table 14). We only included genotypes with a posterior probability above 99%.
Is there something like American Genes, a group of genes that is unique to USA ?
The following NY-times article is the answer.
http://www.nytimes.com/2010/02...
Relevant:
http://www.theroot.com/
http://www.cyberpursuits.com/g...
http://AfricanDNA.com
The Genome Reviews database provides an up-to-date, standardized and comprehensively annotated view of the genomic sequence of organisms with completely deciphered genomes. Currently, Genome Reviews contains the genomes of archaea, bacteria, bacteriophages and selected eukaryota. Genome Reviews is available as a MySQL relational database, or a flat file format derived from that in the EMBL Nucleotide Sequence Database.
MySQL is a convenient platform for open source data transactions. That means genetic data of nearly all available species can be uploaded and retrieved.
Jan. 21, 2010: Toyota recalls 2.3 million Toyota vehicles in a U.S. since a accelerator pedal can stick, causing unintended acceleration. It is not associated to a building pad recall, nonetheless about 1.7 million of a vehicles have been additionally concerned in both recalls. Models concerned have been a 2009-2010 RAV4, 2009-2010 Corolla, 2009-2010 Matrix, 2005-2010 Avalon, sure 2007-2010 Camrys, 2010 Highlander, 2007-2010 Tundra, 2008-2010 Sequoia.
Jan. 26: Toyota at a moment suspends U.S. sales of a 8 models whose accelerator pedals can stick.
It is not as complicated as you think as long as you stick on the recipe.
1. Apply POI (Perturbation Of Interest) to your cells.
This could be a drug treatment, hyper- or hypo- oxia treatment or simply disease cells.
2. Get your normal control, untreated cells ready.
Now we are going to take molecular genetics pictures of your cells.
3. Spin down your cells.
4. Isolate RNA.
5. Get the cDNA copy of the RNA.
The cDNA copy of your cells represents the most recent status of cells of interest. Ready to take the picture.
Amyloid beta (Aβ or Abeta) is a peptide of 39–43 amino acids that appear to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients.
The protein fragment, Aβ, that is broken down in a normal brain, begins to accumulate into tiny clusters known as plaques. These plaques exist between nerve cells in the brain and have the effect of destroying nerve tissue. It has been known for some time that the higher the levels of beta amyloid in the brain the greater the level of brain impairment.
Genetics is a abstract concept. Everybody knows that genetics is about DNA, about genes, diseases and about your children. But the details are obscure to the general public. How genes are associated with diseases ? How a disease is transmitted from your grand parents to your children ? These are important questions.
However, if you try to explain these with scary terminology such as epigenetics, neural pathways, biotechnology, dominant inheritance, gene-methylation you more often scare the average Joe.
Do you remember the modeled characters in AVATAR ? The movie was not science-fiction shoot in a cheap studio. The characters were actual living chracters in silico, in the computer. Human or MA-VI characters were modeled and computers calculated every single move in real-time. This is the digital technology of today.
Imagine, with the ever growing computational power, every single DNA base of your genetic material and every single amino-acid of your flesh and bone is modeled and computers calculate every move of your genes, your muscles, your sperms.
